TY - JOUR PY - 1995// TI - Severe poisoning by 4-aminopyridine in a body builder JO - Nederlands Tijdschrift voor Geneeskunde A1 - Smeets, J. W. A1 - Kunst, M. W. SP - 2667 EP - 2669 VL - 139 IS - 51 N2 - A 22-year-old man was admitted to hospital with severe, accidental intoxication with 4-aminopyridine, a medicine which increases the acetylcholine concentration in the synapses and has a limited application in the treatment of some neurological diseases. The patient acted on the assumption of body-building capacities of this 'amino'. Apart from the previously documented symptoms of intoxication such as an epileptic attack and confusion, he showed cardiac arrhythmias, conduction disorders and severe hypertension. The serum concentration of 4-aminopyridine was 335 mg/l, while the therapeutic level is 25-75 mg/l.

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