TY  - JOUR
PY  - 1993//
TI  - The effects of Benadryl and Hismanal on psychomotor performance and perceived performance
JO  - Aviation, space, and environmental medicine
A1  - Rice, Valerie J.
A1  - Snyder, H. L.
SP  - 726
EP  - 734
VL  - 64
IS  - 8
N2  - Classic antihistamines (H1 antagonists) have sedative effects and can impair psychomotor performance. It is claimed that Hismanal (astemizole) does not possess central nervous system side effects. A three-factor, repeated measures, double-blind design was used to compare the effects of single oral doses of (1) Benadryl (diphenhydramine)-50 mg, (2) Hismanal-10 mg, and (3) placebo on a battery of 11 cognitive information-processing tasks and performance ratings in 28 healthy men. Performance decrements were seen at 1 h post-Benadryl ingestion on Following Directions (p < 0.05), at 1.5 h on Unstable Tracking (p < 0.05), and at 3 h on serial addition/subtraction (p < 0.05). No decrements in performance were found post-Hismanal. Subjects perceived their performance as poorer following Benadryl ingestion versus placebo and Hismanal for 3 h postingestion (p < 0.05). Results demonstrate performance effects post-Benadryl ingestion for 1 h longer than previously reported. Tasks which demonstrated sensitivity to antihistamines were those which required an element of sustained attention and those which required a visual-motor response.<p /> <p>Language: en</p> 
LA  - en
SN  - 0095-6562
UR  - http://dx.doi.org/
ID  - ref1
ER  -