TY  - JOUR
PY  - 1993//
TI  - Acute accidental overdosage of haloperidol in children
JO  - Acta paediatrica
A1  - Yoshida, I.
A1  - Sakaguchi, Y.
A1  - Matsuishi, T.
A1  - Yano, E.
A1  - Yamashita, Y.
A1  - Hayata, S.
A1  - Hitoshi, T.
A1  - Yamashita, F.
SP  - 877
EP  - 880
VL  - 82
IS  - 10
N2  - We report the details of an accidental overdosage of haloperidol in 24 children in one hospital in Kyushu, Japan. Evidence of acute toxicity included disturbances in consciousness (24/24), tremors in the extremities (16/24), an oculogyric or similar crisis (14/24), dysarthria (9/17), drooling (8/24), akathisia (6/20), hyperreflexia (6/24) and opisthotonos (3/24). Laboratory examinations revealed late-onset transient thrombocytosis (5/24), elevated AST and GPT (1/24) and abnormal ECG with prolonged QT interval in 2 of 8 children. We detected haloperidol in 11 of 18 children whose blood was specifically examined within four days after the final haloperidol administration. The maximum serum haloperidol level was 28.9 ng/ml. The mean half-life of haloperidol in the serum of five children (age range 2-10 years) was 18.6 +/- 12.2 h (mean +/- SD) (range 9.1-39.4 h).<p /> <p>Language: en</p> 
LA  - en
SN  - 0803-5253
UR  - http://dx.doi.org/
ID  - ref1
ER  -