TY  - JOUR
PY  - 2010//
TI  - The enhancement of contextual fear conditioning by ABT-418
JO  - Behavioural pharmacology
A1  - Kenney, Justin W.
A1  - Wilkinson, Derek S.
A1  - Gould, Thomas J.
SP  - 246
EP  - 249
VL  - 21
IS  - 3
N2  - Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.<p />  <p>Language: en</p>
LA  - en
SN  - 0955-8810
UR  - http://dx.doi.org/10.1097/FBP.0b013e32833a5b9d
ID  - ref1
ER  -