TY  - JOUR
PY  - 2009//
TI  - REM sleep without Atonia in Narcolepsy
JO  - Neuro endocrinology letters
A1  - Buskova, Jitka
A1  - Nevsimalova, Sona
A1  - Kemlink, David
A1  - Sonka, Karel
SP  - 
EP  - 
VL  - 30
IS  - 6
N2  - Objectives: While there are a number of observations/quantifications indicating a greater proportion of REM sleep without atonia (RWA) in narcolepsy, the intra-night distribution of this parameter has not been evaluated. Material and methods: Thirty-four patients (15 men and 19 women; mean age 44.9 +/- 18.9) with narcolepsy-cataplexy were included in this retrospective study. The clinical diagnosis was confirmed by MSLT, video-polysomnography and HLA typing. Polysomnographic recordings were scored with particular regard to REM sleep without atonia (RWA) across all the nocturnal REM periods. RWA scoring was done according to a standard method. Results: The analysis showed a significant increase in the proportion of REM sleep without atonia during successive nocturnal REM periods in narcoleptic patients (p<0.01). No correlation was found between the percentage of RWA and the severity or duration of the disease, no age effect was documented. Conclusion: The study demonstrates for the first time an increasing amount of RWA during the night suggesting enhanced nocturnal REM sleep motor disturbance.<p />  <p>Language: en</p>
LA  - en
SN  - 0172-780X
UR  - http://dx.doi.org/
ID  - ref1
ER  -