TY  - JOUR
PY  - 2009//
TI  - Cognitive impulsivity in Parkinson's disease patients: Assessment and pathophysiology
JO  - Movement disorders
A1  - Robert, G.
A1  - Drapier, Dominique
A1  - Verin, Marc
A1  - Millet, Bruno
A1  - Azulay, Jean-Philippe
A1  - Blin, Olivier
SP  - 2316
EP  - 2327
VL  - 24
IS  - 16
N2  - Impulsivity may be induced by therapeutic interventions (dopamine replacement therapies and sub-thalamic nucleus (STN) stimulation) in patients with Parkinson's disease (PD). The present review has two goals. First, to describe the most frequently encountered facets of cognitive impulsivity and to stress the links between cognitive impulsivity and aspects such as reward-related decision making, risk-taking, and time-processing in healthy population. The most widely used related cognitive impulsivity paradigms are presented. Second, to review the results of studies on cognitive impulsivity in healthy volunteers and in patients with PD, the latter support the applicability and clinical relevance of this construct in PD population. Data show that PD treatments may favor impulsivity via different mechanisms. Suggestions on the roles of dopamine and STN in the pathophysiology of cognitive impulsivity are proposed. (c) 2009 Movement Disorder Society.<p />  <p>Language: en</p>
LA  - en
SN  - 0885-3185
UR  - http://dx.doi.org/10.1002/mds.22836
ID  - ref1
ER  -