TY  - JOUR
PY  - 1992//
TI  - Reduced neuropeptide Y concentrations in suicide brain
JO  - Journal of neurochemistry
A1  - Widdowson, P. S.
A1  - Ordway, G. A.
A1  - Halaris, A. E.
SP  - 73
EP  - 80
VL  - 59
IS  - 1
N2  - Neuropeptide Y (NPY) was measured in postmortem brain tissue from victims of suicide and from individuals dying a sudden natural or accidental death (controls). Concentrations of NPY-immunoreactivity were measured by radioimmunoassay in frontal cortex (BA 10), temporal cortex (BA 22), caudate nucleus, and cerebellum. Concentrations of NPY-immunoreactivity were significantly lower in postmortem frontal cortex (-14%) and caudate nucleus (-27%) from suicide victims compared with age-matched controls. A subgroup of suicides with evidence of a history of depression revealed more robust reductions in concentrations of NPY-immunoreactivity in frontal cortex and caudate nucleus, as did four individuals who died from natural causes and also were described as having a possible history of depression. Concentrations of NPY-immunoreactivity in temporal cortex and cerebellum from victims of suicide or from the subgroup of subjects with a possible history of depression were not significantly different from those of age-matched controls. We suggest there is a deficit in the brain NPY system leading to region-specific reductions in peptide concentrations in subjects who have a history of depression.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3042
UR  - http://dx.doi.org/
ID  - ref1
ER  -