TY - JOUR PY - 1991// TI - Fatal acetaminophen poisoning with evidence of subendocardial necrosis of the heart JO - Journal of forensic sciences A1 - Price, L. M. A1 - Poklis, A. A1 - Johnson, D. E. SP - 930 EP - 935 VL - 36 IS - 3 N2 - The authors describe a case of fatal acetaminophen overdose which occurred in a 16-year-old female. Her serum acetaminophen concentration 11.5 h postingestion was 154 mg/L. Antidotal therapy was unsuccessful, and after 9 days she died. Autopsy findings included centrilobular zonal liver necrosis, acute proximal renal tubular necrosis, and diffuse alveolar pulmonary damage. Her heart was transplanted into a young woman with congenital heart disease. The recipient expired 14 days after the transplant as a result of sepsis complicating bowel ischemia. The transplanted heart showed extensive subendocardial myocyte necrosis related to acetaminophen toxicity and not rejection.
Language: en
LA - en SN - 0022-1198 UR - http://dx.doi.org/ ID - ref1 ER -