TY - JOUR PY - 1991// TI - Toxicological analysis of a fatal baclofen (Lioresal) ingestion JO - Journal of forensic sciences A1 - Fraser, A. D. A1 - MacNeil, W. A1 - Isner, A. F. SP - 1596 EP - 1602 VL - 36 IS - 5 N2 - A fatality following ingestion of the drug baclofen (Lioresal) is described. Baclofen was identified in urine by gas chromatography/mass spectrometry. After derivatization with trinitrobenzene sulfonic acid, baclofen was quantitated in serum and urine by high-performance liquid chromatography. The concentration of baclofen was 17 mg/L in serum and 760 mg/L in urine collected approximately 12 h after the overdose. To our knowledge, this is only the second reported fatality involving a baclofen overdose. The previous case did not include quantitation of baclofen in any biological fluid.

Language: en

LA - en SN - 0022-1198 UR - http://dx.doi.org/ ID - ref1 ER -