TY  - JOUR
PY  - 1991//
TI  - Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment
JO  - Journal of the American Academy of Child and Adolescent Psychiatry
A1  - King, Robert A.
A1  - Riddle, M. A.
A1  - Chappell, P. B.
A1  - Hardin, M. T.
A1  - Anderson, George M.
A1  - Lombroso, P.
A1  - Scahill, L.
SP  - 179
EP  - 186
VL  - 30
IS  - 2
N2  - Self-injurious ideation or behavior appeared de novo or intensified during fluoxetine treatment of obsessive-compulsive disorder in six patients, age 10 to 17 years old, who were among 42 young patients receiving fluoxetine for obsessive-compulsive disorder at a university clinical research center. These symptoms required the hospitalization of four patients. Before receiving fluoxetine, four patients had major risk factors for self-destructive behavior including depression or prior suicidal ideation or self-injury. Three hypotheses concerning the apparent association between fluoxetine and these self-injurious phenomena are discussed: (1) coincidence; (2) disorganization of vulnerable individuals secondary to drug-induced activation; and (3) a specific serotonergic-mediated effect on the regulation of aggression.<p />  <p>Language: en</p>
LA  - en
SN  - 0890-8567
UR  - http://dx.doi.org/
ID  - ref1
ER  -