TY  - JOUR
PY  - 1991//
TI  - Mental disorders among alcoholics. Relationship to age of onset and cerebrospinal fluid neuropeptides
JO  - Archives of general psychiatry
A1  - Roy, Alec
A1  - DeJong, Jocelyn
A1  - Lamparski, D.
A1  - Adinoff, B.
A1  - George, T.
A1  - Moore, V.
A1  - Garnett, D.
A1  - Kerich, M.
A1  - Linnoila, M.
SP  - 423
EP  - 427
VL  - 48
IS  - 5
N2  - Eighty-one percent of 339 alcoholics participating in a research program were found to have associated mental disorders. Alcoholics with onset of heavy drinking before 20 years of age had significantly more antisocial personality traits, drug abuse, bipolar disorder, panic disorder, suicide attempts, and paternal alcoholism than alcoholics with onset after age 20 years. Alcoholics with onset before and after 20 years of age also differed significantly from each other for cerebrospinal fluid concentrations of diazepam-binding inhibitor and somatostatin. These results support the notion that age of onset may delineate subgroups of alcoholics with significant clinical and neurochemical differences.<p />  <p>Language: en</p>
LA  - en
SN  - 0003-990X
UR  - http://dx.doi.org/
ID  - ref1
ER  -