TY  - JOUR
PY  - 1987//
TI  - Benzodiazepine receptor and neurotransmitter studies in the brain of suicides
JO  - Life Sciences
A1  - Manchon, M.
A1  - Kopp, N.
A1  - Rouzioux, J. J.
A1  - Lecestre, D.
A1  - Deluermoz, S.
A1  - Miachon, S.
SP  - 2623
EP  - 2630
VL  - 41
IS  - 24
N2  - The characteristics of benzodiazepine binding sites (affinity, number heterogeneity) were studied on frozen sections of hippocampus of 7 suicides and 5 controls subjects, using biochemical and autoradiographic techniques. 3H flunitrazepam was used as ligand, clonazepam and CL 218,872 as displacing agents. Some neurotransmitters or their derivatives (GABA, catecholamines, hydroxy-indols) were evaluated quantitatively in parallel in the hippocampal tissue by liquid chromatography. We observed mainly an increase in the Ki of CL 218,872 subtype I binding sites in suicides, (7.48 +/- 1.7 to 17.24 +/- 1.7 nM, P less than 0.01), (m +/- SEM) and an increase in % of type I binding sites (30 +/- 4.2 to 42 +/- 2.5, P = 0.01). Among neurotransmitters, only norepinephrine differed significantly between controls and suicides (11.34 +/- 1.9 to 24.34 ng/g tissue, P = 0.02).<p /> <p>Language: en</p> 
LA  - en
SN  - 0024-3205
UR  - http://dx.doi.org/
ID  - ref1
ER  -