TY - JOUR PY - 1987// TI - Naltrexone decreases self-injurious behavior JO - Annals of neurology A1 - Herman, B. H. A1 - Hammock, M. K. A1 - Arthur-Smith, A. A1 - Egan, Jonathan A1 - Chatoor, I. A1 - Werner, A. A1 - Zelnik, N. SP - 550 EP - 552 VL - 22 IS - 4 N2 - The effect of naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg) on the frequency of self-injurious behavior (SIB) was investigated in three male adolescents. The frequency of total SIB was reduced significantly in all three subjects; dose-dependent decreases (at 0.5, 1.0, and 1.5 mg/kg) in SIB frequency were observed in the two mentally retarded subjects. These data suggest a role for opioid peptides in SIB.
Language: en
LA - en SN - 0364-5134 UR - http://dx.doi.org/10.1002/ana.410220419 ID - ref1 ER -