TY  - JOUR
PY  - 2007//
TI  - Serum levels of olanzapine in a non-fatal overdose
JO  - Journal of analytical toxicology
A1  - Lennestål, Roland
A1  - Asplund, Chad
A1  - Nilsson, M.
A1  - Lakso, Hans-Ake
A1  - Mjörndal, Tom
A1  - Hägg, Staffan
SP  - 119
EP  - 121
VL  - 31
IS  - 2
N2  - Olanzapine is a widely used second generation antipsychotic drug. Case reports of intoxications have been published, but reports in the literature of non-fatal intoxications of olanzapine containing repeated measurements of serum levels are scarce. Therefore, this case of non-fatal olanzapine intoxication is presented, in which 19 blood samples were drawn during 2 weeks. The highest (initial) measured value was estimated at 800 pg/L. This patient ingested 550 mg of olanzapine resulting in clinical signs of intoxication, including seizures. Because the patient was found the day after the intoxication, the initial concentration had probably been higher. The pharmacokinetics of olanzapine has been described as linear and dose-proportional throughout the therapeutic dosing range. Large overdoses, however, have been described to show non-linear pharmacokinetics. In this study's series of serum concentrations, a two-phase elimination was seen, with an initial elimination half-life of about 24 h during the first 3 days, followed by a second phase with a half-life of about 2.5 days. The patient in this case recovered completely. Because the elimination time after intoxication can be considerably longer than expected, it is recommended that the patient's serum concentrations after intoxication be monitored.<p />  <p>Language: en</p>
LA  - en
SN  - 0146-4760
UR  - http://dx.doi.org/
ID  - ref1
ER  -