TY  - JOUR
PY  - 2008//
TI  - Detection of levorotatory methamphetamine and levorotatory amphetamine in urine after ingestion of an overdose of selegiline
JO  - Yakugaku Zasshi
A1  - Fujita, Yoshitsugu
A1  - Takahashi, K.
A1  - Takei, Masao
A1  - Niitsu, Hisae
A1  - Aoki, Yasuhiro
A1  - Onodera, Makoto
A1  - Fujino, Yasuhisa
A1  - Inoue, Y.
A1  - Endo, S.
SP  - 1507
EP  - 1512
VL  - 128
IS  - 10
N2  - In this study, we measured the urine concentrations of methamphetamine and amphetamine as metabolites of selegiline after ingestion of an overdose of selegiline. A patient who had developed Parkinson disease took selegiline in a suicide attempt. Analysis by gas chromatography-mass spectrometry (GC-MS) with trifluoroacetic acid-derivatization revealed the presence of methamphetamine and amphetamine in the patient's urine at concentrations of 0.62 microg/ml and 0.25 microg/ml, respectively. To determine the stereospecificity of the methamphetamine and amphetamine, a urine sample was analyzed by GC-MS after derivatization with N-(trifluoroacetyl)-l-prolyl chloride. The methamphetamine and amphetamine were levorotatory in form. The ratio of the methamphetamine to amphetamine concentration in the urine was 2.5. This value is consistent with other case reports of ingestion of selegiline, which suggests that the methamphetamine to amphetamine concentration ratio in urine is useful information for indicating use of selegiline.<p />  <p>Language: en</p>
LA  - en
SN  - 0031-6903
UR  - http://dx.doi.org/
ID  - ref1
ER  -