TY  - JOUR
PY  - 2007//
TI  - Are depressed outpatients with and without a family history of substance use disorder different? A baseline analysis of the STAR*D cohort
JO  - Journal of clinical psychiatry
A1  - Davis, Lori L.
A1  - Frazier, Elizabeth C.
A1  - Gaynes, Bradley N.
A1  - Trivedi, Madhukar H.
A1  - Wisniewski, Stephen R.
A1  - Fava, Maurizio
A1  - Barkin, Jennifer
A1  - Kashner, T. M.
A1  - Shelton, Rchard C.
A1  - Alpert, Jonathan E.
A1  - Rush, A. John
SP  - 1931
EP  - 1938
VL  - 68
IS  - 12
N2  - OBJECTIVE: This report compares the baseline demographic and clinical characteristics of outpatients with nonpsychotic major depressive disorder (MDD) and a family history of substance use disorder (SUD) versus those with MDD and no family history of SUD. METHOD: Using data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, we grouped participants with MDD (DSM-IV criteria) according to presence or absence of family history of SUD based on participant report. Between-group comparisons were made of demographic and clinical characteristics, depressive symptoms, and psychiatric co-morbidities. Patients were enrolled from July 2001 until August 2004. RESULTS: Of 4010 participants, 46% had a positive family history of SUD. Those with a positive family history were less likely to be Hispanic (p = .0029) and more likely to be female (p = .0013). They were less educated (p = .0120), less likely to be married (p < .01), and more likely to be divorced (p < .01). They also reported an earlier age at onset of MDD, greater length of illness, and more major depressive episodes (all p < .001). They had an increased likelihood of recurrent MDD, more prior suicide attempts, and more concurrent psychiatric comorbidities, including posttraumatic stress disorder, SUD, and generalized anxiety disorder (all p < .0001). CONCLUSION: Depressed patients with a family history of SUD had a more severe previous course of depression, were more likely to have attempted suicide, and had a greater burden of psychiatric comorbid conditions than patients without such a family history. These findings represent important clinical features to be considered in the evaluation and treatment planning of patients with MDD.<p /> <p>Language: en</p> 
LA  - en
SN  - 0160-6689
UR  - http://dx.doi.org/
ID  - ref1
ER  -