TY  - JOUR
PY  - 2008//
TI  - Association study of the interleukin-1 gene complex and tumor necrosis factor alpha gene with suicide attempts
JO  - Psychiatric genetics
A1  - Saiz, Pilar A.
A1  - García-Portilla, Paz
A1  - Paredes, Begona
A1  - Arango, Celso
A1  - Morales, Blanca
A1  - Alvarez, Victoria
A1  - Coto, Eliecer
A1  - Bascaran, Maria-Teresa
A1  - Bousoño, Manuel
A1  - Bobes, Julia
SP  - 147
EP  - 150
VL  - 18
IS  - 3
N2  - To investigate the association between four functional polymorphisms in interleukin-1 (IL-1) [IL-1 alpha -889 C/T, IL-1 beta +3953 C/T, IL-1RA (86 bp)n] and tumor necrosis factor alpha (TNFalpha) (-308A/G) genes and suicide attempts. Distribution of the aforesaid polymorphisms was analyzed in 193 suicide attempters compared with 420 unrelated healthy controls from Asturias (Northern Spain). Genotypes were determined using standard methods. No significant differences were found in genotype or in allelic distribution of IL-1 alpha, IL-1 beta, IL-1RA, or TNFalpha gene polymorphisms. No relationship was found between genotypes and the impulsivity of the suicide attempt. Estimated IL-1 haplotype frequencies were similar in both groups (likelihood ratio test=13.26, df=14, P=0.506). Our data do not suggest that genetically determined changes in the IL-1 or TNFalpha genes confer increased susceptibility to suicidal behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 0955-8829
UR  - http://dx.doi.org/10.1097/YPG.0b013e3282fb002a
ID  - ref1
ER  -