%0 Journal Article
%T Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients
%J Journal of Traumatic Stress
%D 2007
%A Stein, Murray B.
%A Kerridge, Carol
%A Dimsdale, J. E.
%A Hoyt, David B.
%V 20
%N 6
%P 923-932
%X Acute physical injury is frequently associated with mental health sequelae, which then accentuate disability and worsen functional outcomes. A pharmacological prevention approach to this problem has been proposed. This proof-of-concept study was a double-blind, randomized controlled trial of 14 days of the beta-blocker propranolol (n = 17), the anxiolytic anticonvulsant gabapentin (n = 14), or placebo (n = 17), administered within 48 hours of injury to patients admitted to a surgical trauma center. Of 569 accessible, potentially eligible subjects, 48 (8%) participated. Outcomes assessments were conducted at 1, 4, and 8 months postinjury. Although well tolerated, neither study drug showed a significant benefit over placebo on depressive or posttraumatic stress symptoms. Implications are discussed for future pharmacological prevention studies in survivors of acute traumatic injury.<p /> <p>Language: en</p>
%G en
%I John Wiley and Sons
%@ 0894-9867
%U http://dx.doi.org/10.1002/jts.20270