%0 Journal Article
%T Comparing suicide completion rates in bipolar I versus bipolar II disorder: a systematic review and meta-analysis
%J Journal of affective disorders
%D 2024
%A Dev, Donovan A.
%A Le, Gia Han
%A Kwan, Angela T. H.
%A Wong, Sabrina
%A Arulmozhi, Akhilan
%A Ceban, Felicia
%A Teopiz, Kayla M.
%A Meshkat, Shakila
%A Rosenblat, Joshua D.
%A Guillen-Burgos, Hernan F.
%A Rhee, Taeho Greg
%A Ho, Roger C.
%A Cao, Bing
%A d'Andrea, Giacomo
%A Sundberg, Isak
%A McIntyre, Roger S.
%V ePub
%N ePub
%P ePub-ePub
%X BACKGROUND: Bipolar disorder (BD) has a high disease burden and the highest mortality risk in BD comes from suicide. Bipolar disorder type II (BD-II) has been described as a milder form of bipolar disorder; however, extant literature is inconsistent with this description and instead describe illness burden and notably suicidality comparable to persons with bipolar I disorder (BD-I). Towards quantifying the hazard of BD-II, herein we aim via systematic review and meta-analysis to evaluate the rates of completed suicide in BD-I and BD-II. <br><br>METHOD: We conducted a literature search on PubMed, OVID (Embase, Medline) and PsychINFO databases from inception to June 30th, 2023, according to PRISMA guidelines. Articles were selected based on the predetermined eligibility criteria. A meta-analysis was performed, comparing the risk of completed suicide between individuals diagnosed with BD-I to BD-II. <br><br>RESULTS: Four out of eight studies reported higher suicide completion rates in persons living with BD-II when compared to persons living with BD-I; however, two of the studies reported non-significance. Two studies reported significantly higher suicide completion rates for BD-I than BD-II. The pooled odds ratio of BD-II suicide rates to BD-I was 1.00 [95 % CI = 0.75, 1.34]. LIMITATIONS: The overarching limitation is the small number of studies and heterogeneity of studies that report on suicide completion in BD-I and BD-II. <br><br>CONCLUSION: Our study underscores the severity of BD-II, with a risk for suicide not dissimilar from BD-I. The greater propensity to depression, comorbidity and rapid-cycling course reported in BD-II are contributing factors to the significant mortality hazard in BD-II.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 0165-0327
%U http://dx.doi.org/10.1016/j.jad.2024.06.045