%0 Journal Article
%T In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation
%J Proceedings of the National Academy of Sciences of the United States of America
%D 2019
%A Davis, Margaret T.
%A Hillmer, Ansel
%A Holmes, Sophie E.
%A Pietrzak, Robert H.
%A DellaGioia, Nicole
%A Nabulsi, Nabeel
%A Matuskey, David
%A Angarita, Gustavo
%A Carson, Richard E.
%A Krystal, John H.
%A Esterlis, Irina
%V 116
%N 23
%P 11490-11495
%X Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5 (mGluR5) in pathophysiology of PTSD and suicidality. Using positron emission tomography and [18F]FPEB, we quantified mGluR5 availability in vivo in individuals with PTSD (n = 29) and MDD (n = 29) as a function of suicidal ideation (SI) to compare with that of healthy comparison controls (HC; n = 29). Volume of distribution was computed using a venous input function in the five key frontal and limbic brain regions. We observed significantly higher mGluR5 availability in PTSD compared with HC individuals in all regions of interest (P's = 0.001-0.01) and compared with MDD individuals in three regions (P's = 0.007). mGluR5 availability was not significantly different between MDD and HC individuals (P = 0.17). Importantly, we observed an up-regulation in mGluR5 availability in the PTSD-SI group (P's = 0.001-0.007) compared with PTSD individuals without SI. <br><br>FINDINGS point to the potential role for mGluR5 as a target for intervention and, potentially, suicide risk management in PTSD.<p /><p>Language: en</p>
%G en
%I National Academy of Sciences
%@ 0027-8424
%U http://dx.doi.org/10.1073/pnas.1818871116