%0 Journal Article
%T Predicting outcome following mild traumatic brain injury: protocol for the longitudinal, prospective, observational Concussion Recovery (CREST) cohort study
%J BMJ open
%D 2021
%A Gozt, Aleksandra Karolina
%A Hellewell, Sarah Claire
%A Thorne, Jacinta
%A Thomas, Elizabeth
%A Buhagiar, Francesca
%A Markovic, Shaun
%A Van Houselt, Anoek
%A Ring, Alexander
%A Arendts, Glenn
%A Smedley, Ben
%A Van Schalkwyk, Sjinene
%A Brooks, Philip
%A Iliff, John
%A Celenza, Antonio
%A Mukherjee, Ashes
%A Xu, Dan
%A Robinson, Suzanne
%A Honeybul, Stephen
%A Cowen, Gill
%A Licari, Melissa
%A Bynevelt, Michael
%A Pestell, Carmela F.
%A Fatovich, Daniel
%A Fitzgerald, Melinda
%V 11
%N 5
%P e046460-e046460
%X INTRODUCTION: Mild traumatic brain injury (mTBI) is a complex injury with heterogeneous physical, cognitive, emotional and functional outcomes. Many who sustain mTBI recover within 2 weeks of injury; however, approximately 10%-20% of individuals experience mTBI symptoms beyond this 'typical' recovery timeframe, known as persistent post-concussion symptoms (PPCS). Despite increasing interest in PPCS, uncertainty remains regarding its prevalence in community-based populations and the extent to which poor recovery may be identified using early predictive markers. <br><br>OBJECTIVE: (1) Establish a research dataset of people who have experienced mTBI and document their recovery trajectories; (2) Evaluate a broad range of novel and established prognostic factors for inclusion in a predictive model for PPCS. <br><br>METHODS AND ANALYSIS: The Concussion Recovery Study (CREST) is a prospective, longitudinal observational cohort study conducted in Perth, Western Australia. CREST is recruiting adults aged 18-65 from medical and community-based settings with acute diagnosis of mTBI. CREST will create a state-wide research dataset of mTBI cases, with data being collected in two phases. Phase I collates data on demographics, medical background, lifestyle habits, nature of injury and acute mTBI symptomatology. In Phase II, participants undergo neuropsychological evaluation, exercise tolerance and vestibular/ocular motor screening, MRI, quantitative electroencephalography and blood-based biomarker assessment. Follow-up is conducted via telephone interview at 1, 3, 6 and 12 months after injury. Primary outcome measures are presence of PPCS and quality of life, as measured by the Post-Concussion Symptom Scale and the Quality of Life after Brain Injury questionnaires, respectively. Multivariate modelling will examine the prognostic value of promising factors. ETHICS AND DISSEMINATION: Human Research Ethics Committees of Royal Perth Hospital (#RGS0000003024), Curtin University (HRE2019-0209), Ramsay Health Care (#2009) and St John of God Health Care (#1628) have approved this study protocol. <br><br>FINDINGS will be published in peer-reviewed journals and presented at scientific conferences. TRIAL REGISTRATION NUMBER: ACTRN12619001226190.<p /> <p>Language: en</p>
%G en
%I BMJ Publishing Group
%@ 2044-6055
%U http://dx.doi.org/10.1136/bmjopen-2020-046460