%0 Journal Article
%T An overview of the pediatric toxidromes and poisoning management
%J Current clinical pharmacology
%D 2020
%A Hui, Wun Fung
%A Hon, Kam Lun
%A Leung, Alexander Kc
%V ePub
%N ePub
%P ePub-ePub
%X BACKGROUND: Poisoning is one of the leading causes of childhood morbidity and  mortality worldwide. Despite the advancement of poison detection by modern  investigation methods, the clinical skill of toxidrome recognition by combining the  findings from a detailed history, thorough physical examination, and the results of  basic investigations is still indispensable for the management of children with  suspected poisoning. <br><br>OBJECTIVE: To review pediatric toxidromes and poisoning  management. <br><br>METHODS: A literature search was conducted on PubMed (between February 1  and 15, 2020) with keywords of 'toxidrome' 'poisoning' 'intoxication" "children" and  'pediatric'. The search was customized by applying the appropriate filters so as to  get the most relevant articles to meet the objective of this review article. <br><br>RESULTS: Toxidrome recognition may help to offer a rapid guide to possible  toxicology diagnosis, so that specific antidote can be administered in a timely  manner. This article discusses a few commonly encountered toxidromes in pediatric  poisoning, with an emphasis on the symptomatology and source of exposure. The  antidote and specific management for each toxidrome are also discussed. Although  most patients with intoxication can be managed with close observation, supportive  measures and antidote treatment, it is unfortunate that antidotes are only available  for a limited number of poisons responsible for intoxication. Extracorporeal toxin  removal is being increasingly recognized as a mode of treatment in patients with  rapid deterioration of the clinical condition who are unresponsive to conventional  management. The decision of applying such technique and the choice of removal  modality are frequently individualized due to the paucity of high-level evidence. Various patient and toxin/medication factors involved in the decision-making process  are discussed. <br><br>CONCLUSION: Poisoning is a common cause of pediatric accident and  injury. Physicians should be familiar with common toxidromes and poisoning  management.<p /> <p>Language: en</p>
%G en
%I Bentham Science Publishers
%@ 1574-8847
%U http://dx.doi.org/10.2174/1574884715666201201090210