%0 Journal Article
%T Admission circulating monocytes level is an independent predictor of outcome in traumatic brain injury
%J Brain injury
%D 2018
%A Li, Zhiqi
%A Wu, Xing
%A Wu, Xuehai
%A Yu, Jian
%A Yuan, Qiang
%A Du, Zhuoying
%A Hu, Jin
%V 32
%N 4
%P 515-522
%X OBJECTIVE: The aim of this study was to assess the prognostic value of admission immune cell levels in the peripheral blood in determining outcomes in patients with TBI. <br><br>METHOD: We studied 141 adult patients with mild-to-severe TBI (Glasgow Coma Scale (GCS) 3-15). Patient outcome was assessed using the Extended Glasgow Outcome Scale (GOSE) at 6 months post-injury. The area under the curve (AUC) was used to evaluate the predictive ability of immune cell levels. Uni- and multivariate analyses were performed to assess the independent predictors of 6-month outcome. <br><br>RESULTS: We found that admission monocyte count was not only a better predictor (AUC = 0.778; 95% confidence interval (CI), 0.679-0.858) of favourable outcomes (GOSE 5-8) at 6 months post-injury than were admission haemoglobin (AUC = 0.629; 95% CI, 0.522-0.728) and blood glucose (AUC = 0.616; 95% CI, 0.508-0.716) levels for patients with moderate-to-severe TBI (GCS ≤ 12), but also an independent predictor of 6-month outcome (adjusted odds ratio, 1.35; 95% CI, 1.10-1.65; p = 0.004). <br><br>CONCLUSIONS: The present study suggests that an increase in admission monocyte count is correlated with a favourable 6-month outcome in patients with moderate-to-severe TBI.<p /> <p>Language: en</p>
%G en
%I Informa - Taylor and Francis Group
%@ 0269-9052
%U http://dx.doi.org/10.1080/02699052.2018.1429023