%0 Journal Article
%T Myocardial function at the early phase of traumatic brain injury: a prospective controlled study
%J Scandinavian journal of trauma, resuscitation and emergency medicine
%D 2016
%A Cuisinier, Adrien
%A Maufrais, Claire
%A Payen, Jean-François
%A Nottin, Stephane
%A Walther, Guillaume
%A Bouzat, Pierre
%V 24
%N 1
%P 129-129
%X BACKGROUND: The concept of brain-heart interaction has been described in several brain injuries. Traumatic brain injury (TBI) may also lead to cardiac dysfunction but evidences are mainly based upon experimental and clinical retrospective studies. <br><br>METHODS: We conducted a prospective case-control study in a level I trauma center. Twenty consecutive adult patients with severe TBI were matched according to age and gender with 20 control patients. The control group included adult patients undergoing a general anesthesia for a peripheral trauma surgery. Conventional and Speckle Tracking Echocardiography (STE) was performed within the first 24 post-traumatic hours in the TBI group and PRE/PER-operative in the control group. The primary endpoint was the left ventricle ejection fraction (LVEF) measured by the Simpson's method. Secondary endpoints included the diastolic function and the STE analysis. <br><br>RESULTS: We found similar LVEF between the TBI group and the PER-operative control group (61 % [56-76]) vs. 62 % [52-70]). LV morphological parameters and the systolic function were also similar between the two groups. Regarding the diastolic function, the isovolumic relaxation time was significantly higher in the TBI cohort (125 s [84-178] versus 107 s [83-141], p = 0.04), suggesting a subclinical diastolic dysfunction. Using STE parameters, we observed a trend toward higher strains in the TBI group but only the apical circumferential strain and the basal rotation reached statistical significance. STE-derived parameters of the diastolic function tended to be lower in TBI patients. <br><br>DISCUSSION: No systematic myocardial depression was found in a cohort of severe TBI patients. <br><br>CONCLUSIONS: STE revealed a correct adaptation of the left systolic function, while the diastolic function slightly impaired. TRIAL REGISTRATION: NCT02380482.<p /> <p>Language: en</p>
%G en
%I Holtzbrinck Springer Nature Publishing Group - BMC
%@ 1757-7241
%U http://dx.doi.org/10.1186/s13049-016-0323-3