%0 Journal Article
%T Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants
%J Journal of psychiatric research
%D 2012
%A Božina, N.
%A Jovanović, N.
%A Podlesek, A.
%A Rojnić Kuzman, M.
%A Kudumija Slijepčević, M.
%A Roguljić, A.
%A Dimitrović, A.
%A Božina, T.
%A Lovrić, J.
%A Ljubić, H.
%A Medved, V.
%V 46
%N 6
%P 767-773
%X AIM: To examine the role of 5-HTTLPR, rs25531 and 5-HTT VNTR Intron 2 variants in subjects with psychotic disorders manifesting suicide ideation and behaviour. METHODS: The study included 519 subsequently hospitalized subjects who were genotyped for 5-HTTLPR, rs25531 and 5-HTT VNTR In2 variants. Clinical assessments included structured psychiatric interview, sociodemographic characteristics, suicide ideation and behaviour (SIBQ), severity of psychopathology (PANSS) and depression (CDSS). RESULTS: Three subgroups were identified: suicide attempters (N = 161), suicide ideators (N = 174) and subjects who never reported suicide ideation or behaviour (comparative group, N = 184). Major findings: 1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution. CONCLUSION: The suicide ideators, attempters and controls did not differ significantly in 5-HTTLPR or 5-HTT VNTR In 2 variants, but 5-HTTLPR/5-HTT rs25531 haplotype might be a useful genetic marker in distinguishing these three clinical groups.<p /> <p>Language: en</p>
%G en
%I Elsevier Publishing
%@ 0022-3956
%U http://dx.doi.org/10.1016/j.jpsychires.2012.03.008