@article{ref1,
title="Traumatic brain injury and sleep in military and veteran populations: a literature review",
journal="NeuroRehabilitation",
year="2024",
author="Landvater, Jeremy and Kim, Sharon and Caswell, Keenan and Kwon, Caroline and Odafe, Emamoke and Roe, Grace and Tripathi, Ananya and Vukovics, Christian and Wang, Johnathan and Ryan, Keith and Cocozza, Victoria and Brock, Matthew and Tchopev, Zahari and Tonkin, Brionn and Capaldi, Vincent and Collen, Jacob and Creamer, Jennifer and Irfan, Muna and Wickwire, Emerson and Williams, Scott and Werner, J. Kent",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Traumatic brain injury (TBI) is a hallmark of wartime injury and is related to numerous sleep wake disorders (SWD), which persist long term in veterans. Current knowledge gaps in pathophysiology have hindered advances in diagnosis and treatment. <br><br>OBJECTIVE: We reviewed TBI SWD pathophysiology, comorbidities, diagnosis and treatment that have emerged over the past two decades. <br><br>METHODS: We conducted a literature review of English language publications evaluating sleep disorders (obstructive sleep apnea, insomnia, hypersomnia, parasomnias, restless legs syndrome and periodic limb movement disorder) and TBI published since 2000. We excluded studies that were not specifically evaluating TBI populations. <br><br>RESULTS: Highlighted areas of interest and knowledge gaps were identified in TBI pathophysiology and mechanisms of sleep disruption, a comparison of TBI SWD and post-traumatic stress disorder SWD. The role of TBI and glymphatic biomarkers and management strategies for TBI SWD will also be discussed. <br><br>CONCLUSION: Our understanding of the pathophysiologic underpinnings of TBI and sleep health, particularly at the basic science level, is limited. Developing an understanding of biomarkers, neuroimaging, and mixed-methods research in comorbid TBI SWD holds the greatest promise to advance our ability to diagnose and monitor response to therapy in this vulnerable population.<p /> <p>Language: en</p>",
language="en",
issn="1053-8135",
doi="10.3233/NRE-230380",
url="http://dx.doi.org/10.3233/NRE-230380"
}