@article{ref1,
title="Identifying neurofunctional domains across substance use disorders",
journal="American journal of drug and alcohol abuse encompassing all addictive disorders",
year="2024",
author="Hartwell, Emily E. and Schwandt, Melanie and Nuñez, Yaira Z. and Wetherill, Reagan R. and Kember, Rachel L. and Wiers, Corinde E. and Gelernter, Joel and Kranzler, Henry R.",
volume="",
number="",
pages="1-11",
abstract="BACKGROUND: Substance use disorders (SUDs) are heterogeneous across multiple functional domains. Various frameworks posit that domains (e.g., executive function) contribute to the persistence of SUDs; however, the domains identified in different studies vary.<br><br>OBJECTIVES: We used factor analysis to identify the underlying latent domains present in a large sample (N = 5,244, 55.8% male) with a variety of SUDs to yield findings more generalizable than studies with a narrower focus.<br><br>METHOD: Participants (1,384 controls and 3,860 participants with one or more SUDs including alcohol, cocaine, cannabis, and/or opioid use disorders) completed the Semi-Structured Assessment for Drug Dependence and Alcoholism, the NEO Personality Inventory, and the Wisconsin Card Sorting Test. Exploratory factor analysis (EFA) and fit indices (root mean-squared error of approximation (RMSEA), Comparative Fit Index (CFI), and Tucker-Lewis Index (TLI)) were used to examine different latent variable models. A multiple indicators, multiple causes (MIMIC) approach-tested associations of the latent variables with sociodemographics, substance use, and a history of abuse/neglect.<br><br>RESULTS: A six-factor model (predominant alcohol, predominant cocaine, predominant opioid, externalizing, personality, and executive function) provided the best fit [RMSEA = 0.063 (90% CI 0.060, 0.066), CFI = 0.98, TLI = 0.96]. All factors were moderately correlated (coefficient = 0.25-0.55, p < .05) with the exception of executive function. MIMIC analysis revealed different patterns of associations (all p < .0001) with sociodemographics, substance use, and a history of abuse/neglect among the factors.<br><br>CONCLUSIONS: The domains identified, particularly executive function, were parallel to those observed previously. These factors underscore the heterogeneous nature of SUDs and may be useful in developing more targeted clinical interventions.<p /> <p>Language: en</p>",
language="en",
issn="0095-2990",
doi="10.1080/00952990.2024.2368180",
url="http://dx.doi.org/10.1080/00952990.2024.2368180"
}