@article{ref1,
title="Comparing suicide completion rates in bipolar I versus bipolar II disorder: a systematic review and meta-analysis",
journal="Journal of affective disorders",
year="2024",
author="Dev, Donovan A. and Le, Gia Han and Kwan, Angela T. H. and Wong, Sabrina and Arulmozhi, Akhilan and Ceban, Felicia and Teopiz, Kayla M. and Meshkat, Shakila and Rosenblat, Joshua D. and Guillen-Burgos, Hernan F. and Rhee, Taeho Greg and Ho, Roger C. and Cao, Bing and d'Andrea, Giacomo and Sundberg, Isak and McIntyre, Roger S.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Bipolar disorder (BD) has a high disease burden and the highest mortality risk in BD comes from suicide. Bipolar disorder type II (BD-II) has been described as a milder form of bipolar disorder; however, extant literature is inconsistent with this description and instead describe illness burden and notably suicidality comparable to persons with bipolar I disorder (BD-I). Towards quantifying the hazard of BD-II, herein we aim via systematic review and meta-analysis to evaluate the rates of completed suicide in BD-I and BD-II. <br><br>METHOD: We conducted a literature search on PubMed, OVID (Embase, Medline) and PsychINFO databases from inception to June 30th, 2023, according to PRISMA guidelines. Articles were selected based on the predetermined eligibility criteria. A meta-analysis was performed, comparing the risk of completed suicide between individuals diagnosed with BD-I to BD-II. <br><br>RESULTS: Four out of eight studies reported higher suicide completion rates in persons living with BD-II when compared to persons living with BD-I; however, two of the studies reported non-significance. Two studies reported significantly higher suicide completion rates for BD-I than BD-II. The pooled odds ratio of BD-II suicide rates to BD-I was 1.00 [95 % CI = 0.75, 1.34]. LIMITATIONS: The overarching limitation is the small number of studies and heterogeneity of studies that report on suicide completion in BD-I and BD-II. <br><br>CONCLUSION: Our study underscores the severity of BD-II, with a risk for suicide not dissimilar from BD-I. The greater propensity to depression, comorbidity and rapid-cycling course reported in BD-II are contributing factors to the significant mortality hazard in BD-II.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2024.06.045",
url="http://dx.doi.org/10.1016/j.jad.2024.06.045"
}