@article{ref1,
title="Classics in Neuroimaging: Development of PET Tracers for Imaging Monoamine Oxidases",
journal="ACS chemical neuroscience",
year="2019",
author="Narayanaswami, Vidya and Drake, Lindsey R. and Brooks, Allen F. and Meyer, Jeffrey H. and Houle, Sylvain and Kilbourn, Michael R. and Scott, Peter J. H. and Vasdev, Neil",
volume="10",
number="4",
pages="1867-1871",
abstract="In this Viewpoint, we highlight the history of positron emission tomography (PET) radiotracer development to quantify changes in monoamine oxidase (MAO)-A and -B enzyme expression or activity. MAO-A and MAO-B are critical for understanding monoaminergic pathways in psychiatric addiction disorders, and more recently in neurodegenerative disorders with MAO-B expression in astrogliosis. Unique radiochemical innovations have been shown for neuroimaging of MAOs including the clinical translation of irreversible propargylamine-based suicide inhibitors, application of deuterium-substitution to slow down metabolism, development of trapped metabolite imaging agents, and unique 11C-carbonylation chemistry toward novel high-affinity reversibly binding inhibitors.<p /><p>Language: en</p>",
language="en",
issn="1948-7193",
doi="10.1021/acschemneuro.9b00081",
url="http://dx.doi.org/10.1021/acschemneuro.9b00081"
}