@article{ref1,
title="[Extended hemoperfusion in the treatment of acute carbamazepine intoxication]",
journal="Nefrologia",
year="2010",
author="Peces, R. and Azorín, S. and Peces, C. and Selgas, R.",
volume="30",
number="1",
pages="127-130",
abstract="Carbamazepine is used in the treatment of epilepsy, and also prescribed in neuralgic pain syndromes, and certain affective disorders. Carbamazepine intoxication with suicide attempt is a relatively common clinical problem that can result in coma, respiratory depression, arrhythmia, hemodynamic instability and death. The drug's relatively high molecular weight, elevated volume of distribution and intense protein-binding render it difficult to extracorporeal removal, but published experience with hemoperfusion or hemodialysis present variable results. We describe a case report involving carbamazepine intoxication who was successfully treated with charcoal hemoperfusion. With this treatment the half-life of carbamazepine was reduced with rapid lowering of carbamazepine levels and clinical improvement. Based on our experience in this patient and a review of previously reported cases, extended charcoal hemoperfusion should be considered for serious carbamazepine intoxication because free as well as bound drug fractions are eliminated via this technique.<p /><p>Language: es</p>",
language="es",
issn="0211-6995",
doi="10.3265/Nefrologia.pre2010.Jan.10217",
url="http://dx.doi.org/10.3265/Nefrologia.pre2010.Jan.10217"
}