@article{ref1,
title="Peroxidase-like catalytic activity of aqueous- and immobilized-Mn(3+)-octabromo-porphyrins on ion-exchange resin supplied as mimetic of horseradish peroxidase",
journal="Chemical and pharmaceutical bulletin",
year="2008",
author="Kitamura, Youji and Mori, Katsuya and Yamamoto, Makiko and Nozaki, Akira and Saito, Madoka and Tsukamoto, Ikuko and Mifune, Masaki and Saito, Yutaka",
volume="56",
number="9",
pages="1364-1366",
abstract="In order to explore the capability of metal porphyrins as an alternative of horseradish peroxidase (HRP), HRP-like activity of three manganese-porphyrins (Mn-Ps) and three Mn-octabromo-porphyrins (Mn-OBPs) was examined in both aqueous and immobilized states. It was found that Mn(3+)-octabromotetrakis(1-methyl-pyridinium-4yl)porphine (Mn-OBTMPyP) has an activity of at least 90% of HRP in an aqueous solution. Mn-OBTMPyP exhibited a catalytic activity even in the presence of hydrogen peroxide without suicide reaction. In addition, Mn-OBTMPyP was revealed to function as an alternative to HRP in the quantitative determination of serum uric acid. These results are of great interest because they indicate that metal-octabromo-porphyrins possibly include promising candidates of artificial enzyme capable of substituting for HRP.<p /><p>Language: en</p>",
language="en",
issn="0009-2363",
doi="10.1248/cpb.56.1364",
url="http://dx.doi.org/10.1248/cpb.56.1364"
}