@article{ref1,
title="[Hemoperfusion in the treatment of acute valproic acid intoxication]",
journal="Nefrologia",
year="2007",
author="Peces, R. and Fernández, E. J. and Sánchez, R. J. and Peces, C. and Montero, A. and Selgas, R.",
volume="27",
number="3",
pages="370-373",
abstract="Valproic acid is increasingly used in the treatment of epilepsy, and also prescribed for bipolar affective disorders, schizoaffective disorders, schizophrenia and migraine prophylaxis. Valproic acid intoxication with suicide attempt is a relatively common clinical problem that can result in coma, respiratory depression, pancytopenia, hemodynamic instability and death. The drug's relatively low molecular weight, small volume of distribution and saturable protein-binding render it potentially amenable to exracorporeal removal (hemodialysis, hemoperfusion or hemofiltration ), but published experience is scarce. We describe a case report involving valproic acid intoxication with ingestion of ethanol, who was successfully treated with charcoal hemoperfusion. With this treatment the half-life of valproic acid was reduced with rapid lowering of valproic acid levels and clinical improvement. Based on our experience in this patient and a review of previously reported cases, charcoal hemoperfusion should be considered for serious valproic acid intoxication because free as well as bound drug fractions are eliminated via this technique.<p /><p>Language: es</p>",
language="es",
issn="0211-6995",
doi="",
url="http://dx.doi.org/"
}