@article{ref1,
title="Propranolol intoxication revealing a Brugada syndrome",
journal="Journal of cardiovascular electrophysiology",
year="2005",
author="Aouate, Philip and Clerc, Jerome and Viard, Philippe and Seoud, Jamal",
volume="16",
number="3",
pages="348-351",
abstract="This is the first report of Brugada syndrome revealed by beta-blocker intoxication. A 24-year-old healthy man ingested propranolol (2.28 g) to commit suicide. After early gastric lavage, electrolytes, cardiac enzymes, chest X-ray, and echocardiography were normal. Dosages of psychotropic drugs were negative. ECG showed a typical coved-type pattern of Brugada syndrome. Follow-up showed partial ECG normalization of the discrete saddleback-type pattern. The ajmaline- test confirmed Brugada syndrome. These ECG modifications may be explained by the stabilizing membrane effect of high concentration of propranolol and/or inhibition of ICaL. This case illustrates the possible deleterious effects of beta-blockers in patients with Brugada syndrome.<p /><p>Language: en</p>",
language="en",
issn="1045-3873",
doi="10.1046/j.1540-8167.2005.40564.x",
url="http://dx.doi.org/10.1046/j.1540-8167.2005.40564.x"
}