@article{ref1,
title="Overdose of aripiprazole, a new type of antipsychotic",
journal="Journal of emergency medicine",
year="2005",
author="Carstairs, Shaun D. and Williams, Saralyn R.",
volume="28",
number="3",
pages="311-313",
abstract="Aripiprazole is the first member of a new class of antipsychotic medications. Unlike other antipsychotics, it acts as a partial agonist at dopamine D(2) and 5-HT(1A) receptors, thereby mitigating most of the adverse reactions such as extrapyramidal side effects and hyperprolactinemia. Additionally, most research to date has suggested a low incidence of QTc prolongation and orthostatic hypotension at therapeutic doses. Experience in the setting of intentional overdose, however, is limited. We present a case of a 27-year-old woman who intentionally ingested 330 mg of aripiprazole in a suicide attempt. Clinical effects were limited to mild sedation. Serum levels performed by the drug's manufacturer confirmed a total level (parent drug and active metabolite) of 716 ng/mL, nearly six times the upper limit of accepted therapeutic levels. This suggests that aripiprazole's therapeutic index is quite high and reinforces the drug's known safety profile.<p /><p>Language: en</p>",
language="en",
issn="0736-4679",
doi="10.1016/j.jemermed.2004.09.013",
url="http://dx.doi.org/10.1016/j.jemermed.2004.09.013"
}