@article{ref1,
title="Metaraminol (Aramine) in the management of a significant amlodipine overdose",
journal="Human and experimental toxicology",
year="2005",
author="Wood, D. M. and Wright, K. D. and Jones, A. L. and Dargan, P. I.",
volume="24",
number="7",
pages="377-381",
abstract="OBJECTIVE: To report a patient with a significant amlodipine self-poisoning who failed to clinically respond to conventional treatment and was managed with metaraminol (Aramine). PATIENT: A 43-year old male presenting after ingestion of 560 mg amlodipine, who failed to respond clinically to treatment with fluid resuscitation, calcium salts, glucagon and norepinephrine/epinephrine inotropic support. MAIN RESULTS: Following a loading bolus of 2 mg and intravenous infusion (83 microg/min) of metaraminol (Aramine) there was improvement in his blood pressure, cardiac output and urine output. CONCLUSIONS: This is the first case report of the beneficial use of metaraminol (aramine) in the management of significant amlodipine poisoning unresponsive to conventional therapy.<p /><p>Language: en</p>",
language="en",
issn="0960-3271",
doi="10.1191/0960327105ht538oa",
url="http://dx.doi.org/10.1191/0960327105ht538oa"
}