@article{ref1,
title="Case of polymorphic ventricular tachycardia in diphenhydramine poisoning",
journal="Journal of cardiovascular electrophysiology",
year="2004",
author="Joshi, Ajay K. and Sljapic, Tatjana and Borghei, Hassan and Kowey, Peter R.",
volume="15",
number="5",
pages="591-593",
abstract="This is the first reported case of torsades de pointes attributable to diphenhydramine, a drug with weak I(Kr) effects. A 26-year-old, healthy man was admitted to intensive care after a diphenhydramine overdose. <br><br>RESULTS of physical examination, ECG, and electrolytes were normal at admission. Despite supportive care, he developed typical, sustained, torsades de pointes with a markedly prolonged QT interval requiring cardioversion. Drugs with weak I(Kr)-blocking effects may cause lethal proarrhythmia in susceptible individuals when delivered in high concentrations. This case illustrates the variation in repolarization reserve that exists in a free-standing population.<p /><p>Language: en</p>",
language="en",
issn="1045-3873",
doi="10.1046/j.1540-8167.2004.03173.x",
url="http://dx.doi.org/10.1046/j.1540-8167.2004.03173.x"
}