@article{ref1,
title="Analysis of metformin in antemortem serum and postmortem specimens by a novel HPLC method and application to an intoxication case",
journal="Journal of analytical toxicology",
year="2003",
author="Moore, Karla A. and Levine, Barry and Titus, Jack M. and Fowler, David R.",
volume="27",
number="8",
pages="592-594",
abstract="A case of intoxication from the oral hypoglycemic drug metformin is presented. A number of published liquid chromatographic methods were combined to enable a simplified analysis of metformin in both antemortem and postmortem specimens. The method involved direct injection of a protein-free filtrate into the liquid chromatograph. The method was sufficiently sensitive to detect therapeutic use of metformin; no common therapeutic or abused drugs interfered with the assay. In the presented case, the hospital admission serum metformin concentration was 141 mg/L, or approximately two orders of magnitude above therapeutic concentrations. The medical examiner concluded that the cause of death in this case was metformin intoxication, and the manner of death was suicide.<p /><p>Language: en</p>",
language="en",
issn="0146-4760",
doi="10.1093/jat/27.8.592",
url="http://dx.doi.org/10.1093/jat/27.8.592"
}