@article{ref1,
title="LC-MS determination of oxydemeton-methyl and its main metabolite demeton-S-methylsulfon in biological specimens--application to a forensic case",
journal="Journal of analytical toxicology",
year="2002",
author="Beike, J. and Ortmann, Ch and Meiners, Th and Brinkmann, B. and Kohler, H.",
volume="26",
number="5",
pages="308-312",
abstract="A sensitive method for the identification and quantitation of the organophosphate insecticide oxydemeton-methyl and its metabolite demeton-S-methylsulfon from human blood and various tissue samples has been established. After solid-phase extraction using C18 cartridges the extracts were analyzed by high-performance liquid chromatography with mass selective detection (Finnigan MAT LCQ). The method was completely validated. The limit of detection is 1 ng/g blood for the parent substance oxydemeton-methyl and 2 ng/g blood for the metabolite demeton-S-methylsulfon. This method was applied for the analysis of blood and tissue samples of a 58-year-old man who died after the intake of Metasystox R-Spezial, a product from Bayer containing oxydemeton-methyl. Because of a prolonged interval between the ingestion and death, the concentrations of oxydemeton-methyl and demeton-S-methylsulfon were very low. Although the body was already putrefied when the autopsy was performed, the chromatograms of blood and tissue samples were free of interfering peaks.<p /><p>Language: en</p>",
language="en",
issn="0146-4760",
doi="10.1093/jat/26.5.308",
url="http://dx.doi.org/10.1093/jat/26.5.308"
}