@article{ref1,
title="Analysis of fenthion in postmortem samples by HPLC with diode-array detection and GC-MS using solid-phase extraction",
journal="Journal of analytical toxicology",
year="1998",
author="Meyer, E. and Borrey, D. and Lambert, W. and Van Peteghem, C. and Piette, M. and De Leenheer, A.",
volume="22",
number="3",
pages="248-252",
abstract="Fenthion (O,O-dimethyl-O-[3-methyl-4-(methylthio)-phenyl]-thiophos-phate ) is an organophosphate insecticide. A specific method to quantitate fenthion in postmortem matrices with solid-phase extraction combined with high-performance liquid chromatography-diode-array detection (HPLC-DAD) and gas chromatography-mass spectrometry (GC-MS) is presented. Fenitrothion (O,O-dimethyl-O-[3-methyl-4-nitrophenyl]-thiophosphate) is selected as the internal standard. For sample cleanup, a simple but selective solid-phase extraction is chosen after comparison with traditional liquid-liquid extraction procedures. Homogenized and appropriately diluted aqueous samples are applied, and the analytes are desorbed with 5 mL of dichloromethane. Aliquots of the extract are used for HPLC-DAD and GC-MS analysis, Liquid and GC conditions are as follows: gradient elution with a mixture of methanol and water (10:90 to 90:10, v/v) containing 0.0125M NaOH on an Aluspher RP-Select B column monitoring at 250 nm, and temperature programming from 60 to 300 degrees C on a dimethylpolysiloxane column in the SCAN mode, respectively. This method is applied to a suicidal case involving unsuspected acute intoxication with fenthion (concentration in blood, 3.8 micrograms/mL).<p /><p>Language: en</p>",
language="en",
issn="0146-4760",
doi="10.1093/jat/22.3.248",
url="http://dx.doi.org/10.1093/jat/22.3.248"
}