@article{ref1,
title="Hepatotoxicity of N, N-dimethylformamide (DMF) in acute poisoning with the veterinary euthanasia drug T-61",
journal="Human and experimental toxicology",
year="1996",
author="Buylaert, W. and Calle, P. and De Paepe, P. and Verstraete, A. and Samyn, N. and Vogelaers, D. and Vandenbulcke, M. and Belpaire, F.",
volume="15",
number="8",
pages="607-611",
abstract="1. We report on a patient who was resuscitated after a suicide attempt with the veterinary euthanasia product T-61 and treated with N-acetylcysteine (NAC) to prevent hepatotoxicity from N,N-dimethylformamide (DMF), the solvent of T-61. 2. Serum concentrations of DMF were high as compared with values published on occupational exposure. 3. The patient showed only a transient increase in liver enzymes with eventually a full recovery. 4. The hepatoprotective effect of NAC was studied in a rat model using the rise in serum sorbitol dehydrogenase (SDH) as a marker for DMF-induced hepatotoxicity. 5. Four series of randomized, controlled and double-blind experiments were carried out and consistently showed a lower increase in SDH in NAC-treated animals in each series. The difference was statistically significant only when the data of the 4 series were pooled. This is probably due to the large interindividual variations in the effect of DMF. 6. We hypothesize that in the rat NAC may have a protective effect. Whether NAC is also protective in patients, in which it is administered after exposure to DMF, cannot be concluded from the present experiments.<p /><p>Language: en</p>",
language="en",
issn="0960-3271",
doi="10.1177/096032719601500801",
url="http://dx.doi.org/10.1177/096032719601500801"
}