@article{ref1,
title="Thyroid stimulating hormone response to thyrotropin in prepubertal depression",
journal="Journal of the American Academy of Child and Adolescent Psychiatry",
year="1991",
author="García, M. R. and Ryan, N. D. and Rabinovitch, H. and Ambrosini, P. and Twomey, J. and Iyengar, S. and Novacenko, H. and Nelson, B. and Puig-Antich, J.",
volume="30",
number="3",
pages="398-406",
abstract="In an effort to evaluate whether differences exist in the hypothalamic-pituitary-thyroid axis of depressed children, a thyrotropin releasing hormone (TRH) stimulation test was administered to 55 prepubertal subjects who were divided into three groups matched for age and sex: a depressed group (endogenous N = 15, nonendogenous N = 15), a psychiatric nondepressed control group (N = 16), and a normal control group (N = 9). Each subject was tested at two dosages of TRH, 2 micrograms/kg and 7 micrograms/kg. Increasing age and female sex were positively correlated with a greater thyroid stimulating hormone (TSH) response. TSH response to TRH was examined with subjects reclassified by severe suicidal ideation, severe aggression, and parental history of alcoholism. <br><br>RESULTS of this study are contrasted with the adult psychiatric literature.<p /><p>Language: en</p>",
language="en",
issn="0890-8567",
doi="10.1097/00004583-199105000-00008",
url="http://dx.doi.org/10.1097/00004583-199105000-00008"
}