@article{ref1,
title="Diltiazem and metoclopramide overdose",
journal="Journal of analytical toxicology",
year="1991",
author="Beno, J. M. and Nemeth, D. R.",
volume="15",
number="5",
pages="285-287",
abstract="A fatality resulting from the suicidal ingestion of diltiazem and metoclopramide is described. The decedent was a 25-year-old female with a history of alcoholism and cocaine abuse who overdosed on her mother's medications. On admission she was bradycardiac with severe hypotension and third-degree heart block which progressed to asystole. She was resuscitated but remained comatose until her death four days later. Serum samples from the first 15 h of hospitalization were analyzed for diltiazem and metoclopramide by gas chromatography with nitrogen-phosphorus detection. Diltiazem levels 1 hour post admission were 8.49 mg/L. Diltiazem elimination followed zero-order kinetics with an elimination rate of 0.68 mg/L/h. Metoclopramide levels 1 hour post admission were 4.4 mg/L. Data indicated a biphasic elimination curve for metoclopramide with an initial half-life of 1.3 h and a terminal half-life of 20 h.<p /><p>Language: en</p>",
language="en",
issn="0146-4760",
doi="10.1093/jat/15.5.285",
url="http://dx.doi.org/10.1093/jat/15.5.285"
}