@article{ref1,
title="Uneventful self poisoning with a very high dose of captopril",
journal="Toxicology",
year="1990",
author="Lechleitner, P. and Dzien, A. and Haring, C. and Glossmann, H.",
volume="64",
number="3",
pages="325-329",
abstract="A 43-year-old patient with mild heart failure attempted suicide by ingesting between 5000 and 7500 mg of captopril. Blood pressure oscillated around 100-120/50-75 mmHg and pulse rate showed no tendency to accelerate (75-100/min). The psychiatric examination showed no drug induced psychopathological symptoms. The calculated half-life of captopril was 4.4 h. Seven hours after ingestion of approximately 50 times the maximal therapeutic daily dose of captopril the serum concentration reached 20 micrograms/ml. The calculated amount of absorbed captopril was approximately 5400 mg. Atrial natriuretic factor (ANF) plasma levels were slightly elevated and showed no tendency to increase or to fall.<p /><p>Language: en</p>",
language="en",
issn="0300-483X",
doi="10.1016/0300-483x(90)90124-y",
url="http://dx.doi.org/10.1016/0300-483x(90)90124-y"
}