@article{ref1,
title="Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2",
journal="Journal of medicinal chemistry",
year="1993",
author="Zupan, L. A. and Weiss, R. H. and Hazen, S. L. and Parnas, B. L. and Aston, K. W. and Lennon, P. J. and Getman, D. P. and Gross, R. W.",
volume="36",
number="1",
pages="95-100",
abstract="Haloenol lactones are potent mechanism-based inhibitors of a novel class of calcium-independent phospholipases A2 which have been implicated as the enzymic mediators of membrane dysfunction during myocardial ischemia (Hazen, S. L.; et al. J. Biol. Chem. 1991, 266, 7227-7232). Herein we demonstrate that the ring size, hydrophobic group, and cryptic electrophile in the haloenol lactone moiety are important and modifiable determinants of the inhibitory potency of haloenol lactone-mediated inhibition of calcium-independent phospholipase A2. Direct comparisons between haloenol lactone-mediated inhibition of calcium-independent phospholipase A2 and the absence of inhibition with calcium-dependent phospholipase A2 further underscore the marked differences in the catalytic strategy employed by these two classes of intracellular phospholipases A2.<p /><p>Language: en</p>",
language="en",
issn="0022-2623",
doi="10.1021/jm00053a012",
url="http://dx.doi.org/10.1021/jm00053a012"
}