@article{ref1,
title="Efficacy of various water-soluble chelator molecules in the liposome-mediated macrophage "suicide" technique",
journal="Journal of pharmacological and toxicological methods",
year="1992",
author="van Rooijen, N. and Poppema, A.",
volume="28",
number="4",
pages="217-221",
abstract="In earlier studies, we described a technique for the &quot;in vivo&quot; depletion of macrophages, using liposome-encapsulated dichloromethylene bisphosphonate (C12MBP). The aim of the present study was to compare the effects on macrophages of various other liposome-delivered Ca2+ chelators: EDTA, DTPA, and EGTA. It appeared that both EDTA and DTPA as well as Ca(2+)-and Cu(2+)-EDTA complexes were also effective in the elimination of splenic macrophages when encapsulated in liposomes and intravenously injected. EGTA, a well-known and frequently used Ca2+ chelator, had no effect.<p /><p>Language: en</p>",
language="en",
issn="1056-8719",
doi="10.1016/1056-8719(92)90007-n",
url="http://dx.doi.org/10.1016/1056-8719(92)90007-n"
}