@article{ref1,
title="Androst-5-ene-7,17-dione: a novel class of suicide substrate of aromatase",
journal="Biochemical and biophysical research communications",
year="1992",
author="Numazawa, M. and Mutsumi, A. and Hoshi, K. and Tanaka, Y.",
volume="186",
number="1",
pages="32-39",
abstract="5-En-7-one steroid 1 was found to be a potent inhibitor of aromatase. This along with its 19-hydroxy derivative 7 was characterized as suicide substrate of human placental aromatase (k(inact)'s of 0.069 and 0.058 min-1 and KI's of 143 nM and 11.1 microM, respectively, for steroids 1 and 7). The results suggest that the 19-oxygenation would be involved in the irreversible inactivation of aromatase by the 5-en-7-one steroids.<p /><p>Language: en</p>",
language="en",
issn="0006-291X",
doi="10.1016/s0006-291x(05)80771-5",
url="http://dx.doi.org/10.1016/s0006-291x(05)80771-5"
}