@article{ref1,
title="Brain neuropeptidergic function in suicide victims",
journal="Human psychopharmacology",
year="1996",
author="Arranz, B. and Blennow, K. and Ekman, R. and Eriksson, A. and Marcusson, J.",
volume="11",
number="6",
pages="451-461",
abstract="To examine how neuropeptide dysfunction may account for some of the behavioural and physiological alterations observed in depressive illness, neuropeptide Y (NPY), somatostatin (SOM) and corticotropin-releasing factor (CRF)-like immunoreactivity (LI), was measured in frontal cortex, gyrus cinguli and hypothalamus from 18 suicide victims and 23 matched controls. A high performance liquid chromatography separation of the NPY immunoreactive fragments was also performed. Overall suicides did not show significant differences with respect to the control group. However, a significant increase in NPY-LI was noted in the frontal cortex of those suicides dying from carbon monoxide poisoning. The chromatographic characterization showed a distinctly different NPY-LI peak pattern in the depressed suicides, which suggests the possibility of depression being associated with an alteration in the catabolic products of certain neuropeptidergic systems.<p /><p>Language: en</p>",
language="en",
issn="0885-6222",
doi="10.1002/(sici)1099-1077(199611)11:6<451::aid-hup812>3.0.co;2-%23",
url="http://dx.doi.org/10.1002/(sici)1099-1077(199611)11:6<451::aid-hup812>3.0.co;2-%23"
}