@article{ref1,
title="Endogenous interleukin 10 prevents apoptosis in macrophages during salmonella infection",
journal="Biochemical and biophysical research communications",
year="1995",
author="Arai, T. and Hiromatsu, K. and Nishimura, H. and Kimura, Y. and Kobayashi, N. and Ishida, H. and Nimura, Y. and Yoshikai, Y.",
volume="213",
number="2",
pages="600-607",
abstract="To elucidate the biological roles of endogenous interleukin 10 (IL-10) in macrophage responses during bacterial infection, we examined in vitro effects of neutralizing IL-10 by anti-IL-10 monoclonal antibodies (mAb) on apoptosis of the peritoneal macrophages following Salmonella choleraesuis infection. Marked increments of TNF-α production were observed in the culture supernatant later than 6 h after in vitro culture with anti-IL-10 mAb. These macrophages succumbed to apoptosis at this stage accompanied by marked increment of IL-1 release, despite the expression of higher amount of endogenous heat shock protein 70, an inhibitor of TNF-α-mediated apoptosis. These results suggest that endogenous IL-10 plays an essential role in protection of Salmonella-infected macrophages from autocrine suicide caused by excessive production of TNF-α after killing of Salmonella. © 1995 by Academic Press, Inc.<p /><p>Language: en</p>",
language="en",
issn="0006-291X",
doi="10.1006/bbrc.1995.2174",
url="http://dx.doi.org/10.1006/bbrc.1995.2174"
}