@article{ref1,
title="Free-running psycho-physiologic circadians and three-month pattern in a woman isolated in a cave",
journal="New trends in experimental and clinical psychiatry",
year="1994",
author="Hillman, D.C. and Siffre, M. and Milano, G. and Halberg, F.",
volume="10",
number="3",
pages="127-133",
abstract="In a woman isolated from society in a cave for 103 days, alterations of her time structures (chronomes) of several physiologic variables are recorded: awakening, 'to bed' eating, drinking, defecation, urination, the intermicturition interval, the rates of urinary water and creatinine excretion, the caffeine metabolite ratio, urine temperature and the estimation of 2 minutes. Sleep-wakefulness reveals a wobbly circadian component longer than 24 hours, transiently shortening in the middle of the isolation span. Some other variables also follow a pattern of wobbly circadian free-running. Beyond circadians, the time series of sparse around-the-clock two-minute estimations reveals further a 3-month cycle which, because of its length, is not replicated during the span of isolation from society. Any association between chronome alteration and a psychopathology, eventually associated with suicide, constitutes post hoc reasoning, yet an emotional depression has been found earlier in isolation from society for 2 months or more, albeit without ensuing suicide.<p /><p>Language: en</p>",
language="en",
issn="0393-5310",
doi="",
url="http://dx.doi.org/"
}