@article{ref1,
title="Synthesis of high specific activity tritium labeled (E)‐6‐(bromomethylene)‐tetrahydro‐3‐(1‐naphthalenyl)‐2H‐pyran‐2‐one as a selective probe for calcium‐independent phospholipase a2",
journal="Journal of Labelled Compounds and Radiopharmaceuticals",
year="1992",
author="Durley, R.C. and Parnas, B.L. and Weiss, R.H.",
volume="31",
number="9",
pages="685-691",
abstract="The synthesis of (E)‐6‐(bromomethylene)‐tetrahydro‐3‐([4‐3H]‐1‐naphthalenyl)‐2H‐pyran‐2‐one at a specific activity of 24.0 Ci/mmol is described. This probe was synthesized to determine whether (E)‐6‐(bromomethylene)‐tetrahydro‐3‐(1‐naphthalenyl)‐2H‐pyran‐2‐one inhibits calcium‐independent myocardial phospholipase A2 irreversibly via covalent modification. The material was synthesized in four steps from 1‐naphthalene acetic acid via [4‐3H]‐1‐naphthaleneacetic acid. The yield from [4‐3H]‐1‐naphthaleneacetic acid was 29.7%. The radiochemical purity of the HPLC‐purified final product was 99.5%. Copyright © 1992 John Wiley & Sons, Ltd.<p /><p>Language: en</p>",
language="en",
issn="0362-4803",
doi="10.1002/jlcr.2580310907",
url="http://dx.doi.org/10.1002/jlcr.2580310907"
}